Sulfobutylated beta-cyclodextrin sodium

Sodium sulfobutylated -cyclodextrin yog ib hom anionic thiab dej heev-soluble -cd derivative. Nws tuaj yeem zoo daim foos tsis-kev sib cav nrog cov tshuaj tsis zoo, thiab piv rau cov tshuaj lom neeg tsis txaus ntseeg, thiab muab cov dej ua paug, txo cov dej ua paug, nws muaj cov txiaj ntsig zoo dua, nws muaj cov txiaj ntsig zoo dua, nws muaj cov txiaj ntsig zoo dua, qis dua hemolytic nyhuv thiab qis dua Nephrotoxicity, thiab yog hom tshuaj tshiab zam nrog cov kev thov dav dav.

Cov Lus Qhia Yooj Yim

Khoom npe	Sodium sulfobutyl beta-cyclodextrin
Cov Qauv Zoo	USP-NF 2023, EP 10.3, ENPRABLE Txuj
Tsos thiab duab	Cov hmoov dawb
Cas Tsis tau.	182410-00-0
Molecular Cov Qauv	C₄₂H₇₀-Tsis₃₅(C₄H₈Yog li₃Na) n, uas n sawv cev rau cov degree ntawm kev hloov chaw
Molecular hnyav	1134 + 158n

Khoom nta

Sodium sulfobutylated beta-cyclodextrin kuj tseem hu ua sulugobutyl ether beta-cyclodextrin ntsev. Nws yog sodium ntsev tsim los ntawm beta-cyclodextrin raug alkylated nrog 1, {}} buttanedisulfonic acid ester under alkaline tej yam kev mob. Nws yog anionic hom dej-soluble cyclodextrin derivative. Nws tuaj yeem zoo daim foos tsis-kev sib cav nrog cov tshuaj siv tshuaj yeeb yaj kiab, ua rau muaj cov tshuaj stabilate, ua kom pom kev ruaj khov ntawm cov tshuaj, pov hwm cov tshuaj lom zem, npog qhov ntswg tsis muaj ntxhiab tsw, thiab lwm yam.

Kev tswj hwm txoj kev:Kev txhaj tshuaj ntxiv, kev tswj hwm ntawm qhov ncauj, kev ua haujlwm ntawm Nasal, Ocular cov thawj coj. Nws muaj ib qho tshwj xeeb muaj affinity thiab inclus muaj peev xwm rau cov tshuaj nitrogen-muaj.

Cov khoom lag luam

Solubilization

Qhov nruab nrab, cationic raw cov ntaub ntawv tuaj yeem ua ke nrog sulfobutyl beta-cyclodextrin, yog li nce cov solubility ntawm cov khoom siv cov khoom siv sib txawv hauv 10 txog 25, 000 sij hawm.

Yooj yim tswj hwm

Sulfobutyl beta-cyclodextrin muaj kev txhaj tshuaj zoo heev thiab tuaj yeem tswj hwm los ntawm kev txhaj tshuaj, kev tswj hwm, qhov muag, pleev qhov muag, pleev qhov muag thiab nqus tau.

Kev nyab xeeb zoo

Nyob rau hauv ib txwm muaj xwm txheej, nws tuaj yeem nrawm nrawm thiab tshem tawm tag nrho ntawm ob lub raum tom qab kev tswj hwm. Cov ntaub ntawv kev nyab xeeb los ntawm cov kev sim vitro thiab mob sab nrauv thiab muaj kev pom zoo ntev hauv Vivo tau txais kev pom zoo hauv tib neeg kev npaj khoom.

Zoo ruaj khov

Qhov kev sib cuam tshuam nrog sulfobutyl beta-CyclodExtrin tuaj yeem muab cov khoom muaj txiaj ntsig zoo rau cov khoom siv roj raw hauv solubility rau solubility rau solubility thiab ruaj khov.

Kuaj Tus Qauv

Kuaj cov khoom	USP-NF2024			PH. EUR
Cov Khoom Siv	Dawb lossis Off-Dawb Amorphous Hmoov			Dawb los yog tawm-dawb hygroscopic hmoov
So	Cov khoom no yooj yim soluble hauv dej, me ntsis soluble hauv ethanol, n-hexane, n-butane, acetoniturile, isopropanol thiab ethyl acetate			Yooj yim soluble hauv dej, yuav luag Insoluble nyob rau hauv anhydrous ethanol thiab dichlorometomethane
Daim qhia npe	Infrared spectrum	Cov qauv tshuaj yuav tsum muaj cov qhab sib nqus ib yam li cov kev daws teeb meem		Infrared spectroscopy	Qhia ib qho kev nqus cov qhab sib haum raws li tus qauv
	Ua kua theem	Lub sijhawm ua haujlwm ntawm lub ncov ntawm cov qauv daws teeb meem yuav tsum ua kom haum rau lub sijhawm ntawm cov qauv daws teeb meem
	Qib nruab nrab ntawm kev hloov chaw	Yuav tsum ua raws li cov cai		Lub sodium	Reacts raws li sodium ntsev
	Lub sodium	Rov qab ua rau ntsev ntsev
Zoo siab	95.0%~105.0%			95.0%~105.0%
Ph ntawm aqueous kev daws	30% w \/ v aqueous daws Ph 4. 0-6. 8			5.0~7.5
Cov hlau hnyav	Tsawg dua los yog sib npaug rau 5ppm			N/A
Beta-cyclodextrin	Tsawg dua los yog sib npaug rau 0. 1%			Tsawg dua los yog sib npaug rau 0. 1%
1, {4- butane sultone	Tsawg dua los yog sib npaug rau 0. 5ppm			Tsawg dua los yog sib npaug rau 0. 5ppm
Sodium chloride	Tsawg dua los yog sib npaug rau 0. 2%			Tsawg dua los yog sib npaug rau {{{{0}}}. 12% (chloride, sib npaug rau 0.20% sodium chloride)
4- hydroxybutane -1-}} sulfonic acid	Tsawg dua los yog sib npaug rau 0. 09%			Tsawg dua los yog sib npaug rau 0. 1%
Disodium BIS (4-} sulfobutyl) ether	Tsawg dua li lossis sib npaug rau 0. 05%			Tsawg dua li lossis sib npaug rau 0. 05%
Bacterial endotoxins	Tsawg dua lossis sib luag rau 10eu \/ g			N/A
Tag nrho cov naj npawb ntawm cov kab mob aerobic	Tsawg dua los yog sib npaug rau 100cfu \/ g			Tsawg dua los yog sib npaug rau 100 cfu \/ g (niam txiv kab ke) Tsawg dua los yog sib npaug rau 1000 cfu \/ g (tsis yog niam txiv tsis npaj)
Tag nrho cov pwm thiab cov poov xab	Tsawg dua lossis sib npaug nrog 50cfu \/ g			Tsawg dua los yog sib npaug rau 1000 cfu \/ g (tsis yog niam txiv tsis npaj)
Escherichia coli	Tsis kuaj tau			Tsis kuaj tau
Tus ntses siav	N/A			Tsis kuaj tau
Tshuaj Clarity	30% (w \/ v) kev daws teeb meem			Ntshiab thiab tsis muaj xim
Qib nruab nrab ntawm kev hloov chaw	6.2~6.9			5.9~6.6
Ncov (% Peak Cheeb Tsam)	I		0-0.3	N/A
	'		0-0.9
	I		0.5-5.0
	IV		2.0-10.0
	V		10.0-20.0
	Vi		15.0-25.0
	Download VII		20.0-30.0
	Viii		10.0-25.0
	Ix		2.0-12.0
	X		0-4.0
Ywg dej	Tsawg dua los yog sib npaug rau 1 0. 0%			Tsawg dua los yog sib npaug rau 1 0. 0%
Txo cov piam thaj	N/A			Tsawg dua li lossis sib npaug rau 0. 05%

Ntim thiab Ntim Khoom

Ntim: Hauv kab nrog ntim khoom siv
NTIM SPECIFIEDS: 1 Kilogram ib lub hnab; 2ilrams ib lub hnab; 10 kilograms rau ib lub thoob; 20 kilograms ib lub thoob
Cia: Ntim thiab khaws cia rau hauv qhov chaw qhuav

Cim npe nrov: BetadeX Sulfobutyl Ethe cov sodium, Tuam Tshoj betadeX sulfobutyl ether sodium manufacturers, lwm tus neeg, Hoobkas